{"id":41,"date":"2020-12-17T15:16:13","date_gmt":"2020-12-17T06:16:13","guid":{"rendered":"https:\/\/test-dermatol-h.dept.med.gunma-u.ac.jp\/1_web\/?page_id=41"},"modified":"2025-08-13T18:09:43","modified_gmt":"2025-08-13T09:09:43","slug":"%e5%ae%89%e7%94%b0%e3%82%b0%e3%83%ab%e3%83%bc%e3%83%97","status":"publish","type":"page","link":"https:\/\/dermatol-h.dept.med.gunma-u.ac.jp\/?page_id=41","title":{"rendered":"\u5b89\u7530\u30b0\u30eb\u30fc\u30d7"},"content":{"rendered":"
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\u7814\u7a76\u5ba4\u7d39\u4ecb<\/h4>\n

\u7814\u7a76\u30e1\u30f3\u30d0\u30fcLABORATORY MEMBERS<\/span><\/h5>\n

\u5b89\u7530\u3000\u6b63\u4eba\uff08\u30b0\u30eb\u30fc\u30d7\u8cac\u4efb\u8005\uff09
\n\u6817\u5c71\u3000\u88d5\u5b50
\n\u5c71\u5d0e\u3000\u54b2\u4fdd\u91cc
\n\u4e95\u4e0a\u3000\u88d5\u592a
\n\u9f4b\u85e4\u3000\u664b\u592a\u90ce<\/p>\n<\/section>\n

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\u7814\u7a76\u30c6\u30fc\u30de<\/h4>\n

<\/p>\n

\u8868\u76ae\u89d2\u5316\u6a5f\u69cb\u30fb\u89d2\u5316\u75c7\u7814\u7a76<\/h5>\n
\u90e8\u4f4d\u7279\u7570\u7684\u8868\u76ae\u89d2\u5316\u6a5f\u69cb\u306e\u89e3\u660e<\/h6>\n

\u76ae\u819a\u306e\u6700\u5916\u5c64\u306b\u4f4d\u7f6e\u3059\u308b\u8868\u76ae\u306f\u3001\u4f53\u306e\u5404\u90e8\u4f4d\u306b\u5408\u308f\u305b\u3001\u305d\u306e\u751f\u5316\u5b66\u7684\u7279\u6027\u3084\u7d44\u7e54\u5b66\u7684\u69cb\u9020\u3092\u5927\u304d\u304f\u5909\u5316\u3055\u305b\u3066\u3044\u307e\u3059\u3002 \u4f8b\u3048\u3070\u3001\u624b\u306e\u5e73\u30fb\u8db3\u306e\u88cf\uff08\u638c\u8e60\uff09\u306f\u3001\u4f53\u306e\u76ae\u819a\u3068\u306f\u7570\u306a\u308a\u3001\u539a\u3044\u8868\u76ae\u6709\u68d8\u5c64\u3068\u89d2\u5c64\u3092\u6301\u3064\u3053\u3068\u3067\u5927\u304d\u306a\u8377\u91cd\u3084\u5916\u529b\u306b\u8010\u3048\u3046\u308b\u69cb\u9020\u3092\u3068\u3063\u3066\u3044\u308b\u308f\u3051\u3067\u3059\u3002 Circumscribed palmoplantar hypokeratosis\u306f\u3001\u638c\u8e60\u306e\u76ae\u819a\u306e\u4e00\u90e8\u304c\u4f53\u5e79\u306e\u76ae\u819a\u306e\u3088\u3046\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u7a00\u306a\u76ae\u819a\u75c5\u3067\u3059\u3002\u3053\u306e\u76ae\u819a\u75c5\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u638c\u8e60\u306e\u76ae\u819a\u3068\u4f53\u5e79\u306e\u76ae\u819a\u306e\u9055\u3044\u3092\u660e\u3089\u304b\u306b\u3067\u304d\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059 (Br J Dermatol 2011)\u3002<\/p>\n

\u90e8\u4f4d\u7279\u7570\u7684\u8868\u76ae\u771f\u76ae\u76f8\u4e92\u4f5c\u7528\u306e\u89e3\u6790<\/h6>\n

\u638c\u8e60\u3084\u53e3\u8154\u7c98\u819c\u306a\u3069\u90e8\u4f4d\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u8868\u76ae\u69cb\u9020\u306f\u3001\u305d\u306e\u4e0b\u306e\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u56e0\u5b50\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002 \u3064\u307e\u308a\u3001\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u3082\u304b\u3089\u306e\u90e8\u4f4d\u306b\u3088\u3063\u3066\u3001\u5927\u304d\u304f\u5909\u5316\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u3059\u3002\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u306a\u3069\u306e\u591a\u304f\u306e\u7d30\u80de\u5916\u57fa\u8cea\u3092\u5206\u6ccc\u3059\u308b\u3053\u3068\u3067\u76ae\u819a\u306e\u67d4\u8edf\u6027\u3001\u5f3e\u529b\u6027\u3092\u7dad\u6301\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u307e\u3067\u306b\u79c1\u305f\u3061\u306f\u3001\u4f53\u5e79\u306e\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u306f\u30d5\u30a1\u30a4\u30d6\u30ed\u30cd\u30af\u30c1\u30f3\u3068\u3044\u3046\u7d30\u80de\u5916\u57fa\u8cea\u304c\u3001\u638c\u8e60\u306e\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u306f\u30c7\u30b3\u30ea\u30f3\u3068\u3044\u3046\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u3092\u591a\u304f\u5206\u6ccc\u3059\u308b\u3053\u3068\u3067\u3001\u305d\u306e\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059 (Br J Dermatol 2006, Exp Dermatol 2016)\u3002<\/p>\n

\u4e7e\u766c\u306a\u3089\u3073\u306b\u95a2\u9023\u75be\u60a3\u306e\u81e8\u5e8a\u7814\u7a76<\/h6>\n

\u4e7e\u766c\u306f\u3053\u306e15\u5e74\u3067\u6cbb\u7642\u304c\u6025\u901f\u306b\u9032\u6b69\u3057\u3001\u6cbb\u7642\u85ac\u3082\u5897\u3048\u3066\u304d\u3066\u3044\u307e\u3059\u304c\u3001\u60a3\u8005\u3055\u3093\u4e00\u4eba\u3072\u3068\u308a\u306b\u3068\u3063\u3066\u3001\u3069\u306e\u85ac\u5264\u304c\u9069\u3057\u3066\u3044\u308b\u306e\u304b\u306f\u4f7f\u3063\u3066\u307f\u306a\u3044\u3068\u308f\u304b\u308a\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u3001\u5b9f\u969b\u306b\u60a3\u8005\u3055\u3093\u306b\u5bfe\u3057\u3066\u4f7f\u308f\u308c\u305f\u85ac\u5264\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u3092\u96c6\u7a4d\u3057\u3066\u3044\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u73fe\u5728\u3001\u5f53\u79d1\u3067\u306f\u69d8\u3005\u306a\u85ac\u5264\u306b\u3064\u3044\u3066\u305d\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u81e8\u5e8a\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002
\n\u307e\u305f\u3001\u4e7e\u766c\u306f\u76ae\u819a\u3060\u3051\u3067\u306a\u304f\u3001\u95a2\u7bc0\u3084\u8840\u7ba1\u3001\u8178\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u81d3\u5668\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u5168\u8eab\u6027\u708e\u75c7\u6027\u75be\u60a3\u3068\u8a8d\u8b58\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u80a5\u6e80\u306a\u3069\u306e\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u3068\u306e\u95a2\u9023\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u5185\u5206\u6ccc\u7cd6\u5c3f\u75c5\u5185\u79d1\u3068\u5171\u540c\u3067\u3001\u80a5\u6e80\u75c7\u3092\u5408\u4f75\u3059\u308b\u60a3\u8005\u3055\u3093\u306b\u5bfe\u3057\u3066\u3001\u6804\u990a\u6307\u5c0e\u3084\u6e1b\u91cf\u6307\u5c0e\u306a\u3089\u3073\u306b\u6cbb\u7642\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u4e7e\u766c\u306e\u75c5\u52e2\u3078\u306e\u5f71\u97ff\u3092\u89e3\u6790\u3057\u3088\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002
\n\u3053\u308c\u307e\u3067\u306b\u306f\u3001\u65e5\u672c\u306b\u304a\u3051\u308b\u81bf\u75b1\u6027\u4e7e\u766c\u8a3a\u7642\u306e\u73fe\u72b6\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u6cbb\u7642\u72b6\u6cc1\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306e\u591a\u65bd\u8a2d\u5171\u540c\u7814\u7a76\u306b\u53c2\u52a0\u3057\u3001\u65e5\u672c\u306eGPP\u60a3\u8005205\u4f8b\u309210\u5e74\u9593\u5f8c\u65b9\u8996\u7684\u306b\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u751f\u7269\u5b66\u7684\u88fd\u5264\u4f7f\u7528\u304c25\uff05\u304b\u308980\uff05\u3078\u5897\u52a0\u3057\u3001\u5897\u60aa\u6642\u306b\u306f\u65b0\u898f\u751f\u7269\u5b66\u7684\u88fd\u5264\u304c\u6700\u591a\u3067\u5c0e\u5165\u3055\u308c\u308b\u4e00\u65b9\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\u4f7f\u7528\u4e2d\u3067\u3082\u5897\u60aa\u304c\u751f\u3058\u308b\u4f8b\u304c\u3042\u308b\u3068\u5831\u544a\u3057\u305f\uff08Dermatol Ther 2025\uff09\u3002\u307e\u305f\u3001\u30b0\u30eb\u30fc\u30d7\u8cac\u4efb\u8005\u306e\u5b89\u7530\u306f\u30a2\u30b8\u30a210\u30ab\u56fd\u306e\u76ae\u819a\u79d1\u533b\u3068\u3068\u3082\u306bGPP\u30ef\u30fc\u30af\u30b7\u30e7\u30c3\u30d7\u306b\u53c2\u52a0\u3057\u3001GPP\u306e\u8fc5\u901f\u306a\u5c02\u9580\u533b\u7d39\u4ecb\u3068\u6559\u80b2\u306e\u91cd\u8981\u6027\u306b\u3064\u3044\u3066\u8b70\u8ad6\u3057\u307e\u3057\u305f\uff08Dermatol Ther 2022\uff09
\n\u3055\u3089\u306b\u73fe\u5728\u3001\u7a00\u306a\u708e\u75c7\u6027\u89d2\u5316\u75c7\u3067\u3042\u308b\u6bdb\u5b54\u6027\u7d05\u8272\u7c83\u7ce0\u75b9\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u5b9f\u614b\u3092\u8abf\u67fb\u3059\u308b\u305f\u3081\u306e\u591a\u65bd\u8a2d\u5171\u540c\u7814\u7a76\u3092\u5b9f\u65bd\u3057\u300127\u65bd\u8a2d\u304b\u3089144\u540d\u306e\u81e8\u5e8a\u75c7\u72b6\u3001\u6cbb\u7642\u7d4c\u904e\u306a\u3069\u306e\u60c5\u5831\u3092\u53ce\u96c6\u3057\u3001\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u89d2\u5316\u75c7\u306e\u75c5\u614b\u89e3\u660e<\/h6>\n

\u4e7e\u766c\u3001\u30c0\u30ea\u30a8\u75c5\u3001\u638c\u8e60\u89d2\u5316\u75c7\u306a\u3069\u8868\u76ae\u306b\u7570\u5e38\u3092\u751f\u3058\u308b\u305f\u304f\u3055\u3093\u306e\u75be\u60a3\u304c\u3042\u308a\u3001\u305d\u306e\u75c5\u614b\u306f\u5c11\u3057\u305a\u3064\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u304c\u3001\u6cbb\u7642\u306b\u7d50\u3073\u3064\u3044\u3066\u3044\u308b\u3082\u306e\u306f\u591a\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u5171\u540c\u7814\u7a76\u8005\u3068\u3068\u3082\u306b\u69d8\u3005\u306a\u89d2\u5316\u6027\u75be\u60a3\u306e\u907a\u4f1d\u5b50\u7570\u5e38\u3092\u89e3\u660e\u3057\u3001\u6cbb\u7642\u3078\u306e\u5fdc\u7528\u3092\u6a21\u7d22\u3057\u3066\u3044\u307e\u3059\uff08J Hum Genet 2021; J Dermatol 2022, 2018\uff09\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/h6>\n
    \n
  • Strober B, et al. Unmet Educational Needs and Clinical Practice Gaps in the Management of Generalized Pustular Psoriasis: Global Perspectives from the Front Line. Dermatol Ther 2022; 12, 381\u2013393.<\/li>\n
  • Okubo Y, et al. Treatment Status for Generalized Pustular Psoriasis in Japanese Patients: A Retrospective Chart Review. Dermatol Ther 2025: 15, 1883\u20131899.<\/li>\n
  • Yasuda M<\/strong>, et al. Circumscribed palmar hypokeratosis on both hands: distinct keratin expression in multiple depressed lesions. Br J Dermatol 2011; 164(1): 211-3.<\/li>\n
  • Yasuda M<\/strong>, et al. Spatial expressions of fibronectin and integrins by human and rodent dermal fibroblasts. Br J Dermatol 2006; 155(3): 522-31.<\/li>\n
  • Yasuda M<\/strong>, et al. Palmoplantar collagen bundle size correlated with a characteristic spatial expression of decorin and lumican. Exp Dermatol 2016; 25(4): 318-20.<\/li>\n
  • Tahara U, et al. Autosomal dominant familial acanthosis nigricans caused by a C-terminal nonsense mutation of FGFR3. J Hum Genet 2021; 66(8): 831-834.<\/li>\n
  • Kuriyama Y<\/strong>, et al. Focal palmoplantar keratoderma in a patient with the KRT6B mutation. J Dermatol 2022; 49(3): e111-e112.<\/li>\n
  • Yasuda M<\/strong>, et al. Familial acanthosis nigricans with the FGFR3 mutation: Differences of pigmentation between male and female patients. J Dermatol 2018; 45(11): 1357-1361.<\/li>\n<\/ul>\n<\/section>\n
    \n
    \u76ae\u819a\u60aa\u6027\u816b\u760d\u7814\u7a76<\/h5>\n

    \u76ae\u819a\u60aa\u6027\u816b\u760d\u306f\u3001\u60aa\u6027\u9ed2\u8272\u816b\u3001\u6709\u68d8\u7d30\u80de\u764c\u3001\u57fa\u5e95\u7d30\u80de\u764c\u3001\u4e73\u623f\u5916\u30d1\u30b8\u30a7\u30c3\u30c8\u75c5\u3001\u30a8\u30af\u30ea\u30f3\u6c57\u5b54\u764c\u3001\u30e1\u30eb\u30b1\u30eb\u7d30\u80de\u764c\u306a\u3069\u975e\u5e38\u306b\u591a\u5f69\u3067\u3059\u3002\u591a\u304f\u306e\u5834\u5408\u3001\u624b\u8853\u306b\u3088\u308a\u5207\u9664\u3059\u308b\u3053\u3068\u3067\u6839\u6cbb\u304c\u53ef\u80fd\u3067\u3042\u308a\u3001\u65e9\u671f\u767a\u898b\u304c\u6700\u3082\u91cd\u8981\u3067\u3059\u3002\u79c1\u305f\u3061\u306fcapillaroscopy\u3068\u3044\u3046\u7d30\u3044\u6bdb\u7d30\u8840\u7ba1\u3082\u8a73\u7d30\u306b\u89b3\u5bdf\u3067\u304d\u308b\u9855\u5fae\u93e1\u578b\u30ab\u30e1\u30e9\u3092\u7528\u3044\u3066\u76ae\u819a\u60aa\u6027\u816b\u760d\u306e\u65e9\u671f\u767a\u898b\u3092\u76ee\u6307\u3059\u81e8\u5e8a\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\uff08Acta Derm Venereol 2022\uff09\u3002\u76ae\u819a\u60aa\u6027\u816b\u760d\u306f\u4e00\u3064\u4e00\u3064\u304c\u7a00\u3067\u3042\u308b\u305f\u3081\u3001\u305d\u306e\u75c5\u614b\u3082\u660e\u3089\u304b\u3067\u306a\u304f\u3001\u307e\u305f\u3001\u624b\u8853\u3067\u6839\u6cbb\u3059\u308b\u65b9\u304c\u591a\u3044\u3053\u3068\u304b\u3089\u9032\u884c\u3057\u305f\u5834\u5408\u306e\u6cbb\u7642\u65b9\u6cd5\u3082\u5c11\u306a\u3044\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002\u5358\u4e00\u65bd\u8a2d\u306e\u307f\u3067\u306f\u5341\u5206\u306a\u7814\u7a76\u304c\u884c\u3048\u306a\u3044\u305f\u3081\u3001\u591a\u65bd\u8a2d\u5171\u540c\u3067\u3001\u69d8\u3005\u306a\u76ae\u819a\u60aa\u6027\u816b\u760d\u306e\u75c5\u614b\u89e3\u660e\u3001\u6cbb\u7642\u65b9\u6cd5\u306e\u78ba\u7acb\u306e\u305f\u3081\u306e\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3059\uff08Eur J Surg Oncol 2025; Surgery 2025; JCO Glob Oncol 2025; J Dtsch Dermatol Ges 2022; Eur J Cancer 2021,2020; J Dermatol Sci 2020; J Immunother Cancer 2020; JAMA Dermatol 2015\uff09\u3002
    \n\u5f53\u79d1\u3092\u4e2d\u5fc3\u3068\u3057\u3001\u5168\u56fd27\u65bd\u8a2d\u30672010\u301c2020\u5e74\u306b\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u305f\u5207\u9664\u4e0d\u80fd\u60aa\u6027\u6c57\u5668\u5b98\u816b\u760d81\u4f8b\u3092\u5bfe\u8c61\u3068\u3057\u3066\u30ec\u30c8\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u306b\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u89e3\u6790\u306f\u6cbb\u7642\u306e\u591a\u304b\u3063\u305f\u767d\u91d1\u88fd\u5264\u7cfb\uff0837.0%\uff09\u3001\u30bf\u30ad\u30b5\u30f3\u7cfb\uff0843.2%\uff09\u3001TS-1\uff0812.3%\uff09\u306b\u5206\u3051\u3066\u884c\u3063\u305f\u304c\u594f\u52b9\u7387\uff08ORR\uff09\u3001\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\uff08PFS\uff09\u3001\u5168\u751f\u5b58\u671f\u9593\uff08OS\uff09\u306b\u6709\u610f\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5168\u4f53\u306e\u4e2d\u592e\u5024OS\u306f29.0\u304b\u6708\u30015\u5e74\u751f\u5b58\u7387\u306f34.0%\u3001\u7d44\u7e54\u578b\u5225\u89e3\u6790\u3067\u306f\u6c57\u5b54\u764c\u304c\u72ec\u7acb\u3057\u305f\u4e88\u5f8c\u4e0d\u826f\u56e0\u5b50\u3067\u3042\u308a\u3001\u4e2d\u592e\u5024OS\u304c15.0\u304b\u6708\u3068\u77ed\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08JJCO Glob Oncol 2025\uff09\u3002<\/p>\n

    \u53c2\u8003\u6587\u732e\uff1a<\/h6>\n
      \n
    • Saito S<\/strong>, et al. Effectiveness and prognosis of systemic chemotherapy for unresectable malignant apocrine and eccrine tumors: A real-world multicenter retrospective study. JCO Glob Oncol in press<\/em>.<\/li>\n
    • Koizumi, S. et al. Comparing 2\u00a0cm vs. 1\u00a0cm surgical margins in acral melanoma of the sole with Breslow thickness greater than 2\u00a0mm: A multicenter retrospective study of 336 Japanese patients. Eur J Surg Oncol 2025; 51, 110264.<\/li>\n
    • Koizumi, S. et al. Prognosis of a deep excision margin within or beyond subcutaneous fat for invasive acral melanoma of the sole: A multi-institutional retrospective study. Surgery 2025; 186, 109573.<\/li>\n
    • Koizumi, S. et al. Adjuvant Anti\u2013PD-1 Monotherapy Versus Observation for Stage III Acral Melanoma of the Sole: A Multicenter Retrospective Study in Japanese Patients. JCO Glob Oncol 2025; 11, e2400644.<\/li>\n
    • Saito S<\/strong>,\u00a0et al. Capillaroscopy in Pigmented Basal Cell Carcinoma Smaller than 3-mm Diameter: A Report of Four Lesions. Acta Derm Venereol 2022; 102<\/li>\n
    • Baba N, et al. Narrower clinical margin in high or very high-risk squamous cell carcinoma: a retrospective, multicenter study of 1,000 patients. J Dtsch Dermatol Ges 2022; 20(8):1088-1099.<\/li>\n
    • Fujisawa Y, et al. Outcome of combination therapy using BRAF and MEK inhibitors among Asian patients with advanced melanoma: An analysis of 112 cases. Eur J Cancer 2021; 145: 210-220.<\/li>\n
    • Ogata D, et al. Systemic treatment of patients with advanced cutaneous squamous cell carcinoma: response rates and outcomes of the regimes used. Eur J Cancer 2020; 127: 108-117.<\/li>\n
    • Nakamura M, et al. Increased programmed death ligand-1 expression in metastatic Merkel cell carcinoma associates with better prognosis. J Dermatol Sci 2020; 97(2): 165-167.<\/li>\n
    • Nakamura M, et al. Glucose-6-phosphate dehydrogenase correlates with tumor immune activity and programmed death ligand-1 expression in Merkel cell carcinoma. J Immunother Cancer 2020; 8(2): e001679.<\/li>\n<\/ul>\n
      \u305d\u306e\u4ed6<\/h5>\n

      \u5927\u962a\u5927\u5b66\u3001\u5c71\u5f62\u5927\u5b66\u3001\u5ca1\u5c71\u5927\u5b66\u3068\u5171\u540c\u3067\u30012013\u5e74\u306b\u793e\u4f1a\u554f\u984c\u3068\u306a\u3063\u305f\u30ed\u30c9\u30c7\u30ce\u30fc\u30eb\u914d\u5408\u5316\u7ca7\u54c1\u306b\u3088\u308a\u751f\u3058\u305f\u767d\u6591\u306b\u3064\u3044\u3066\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\uff08J Dermatol Sci 2020\uff09\u3001\u307e\u305f\u3001\u682a\u5f0f\u4f1a\u793e\u8cc7\u751f\u5802\u3068\u5171\u540c\u3057\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308b\u76ae\u819a\u306e\u5909\u5316\uff08\u5149\u8001\u5316\uff09\u304c\u3001\u8868\u76ae\u771f\u76ae\u63a5\u5408\u90e8\u306b\u304a\u3051\u308b\u30e9\u30df\u30cb\u30f3511\u306e\u4f4e\u4e0b\u3092\u4ecb\u3057\u3066\u3001\u8868\u76ae\u5e79\u7d30\u80de\u306e\u6e1b\u5c11\u3092\u304d\u305f\u3059\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08Sci Rep 2020\uff09\u3002<\/p>\n

      \u53c2\u8003\u6587\u732e\uff1a<\/h6>\n
        \n
      • Yasuda M<\/span><\/strong>, Sekiguchi A, Kishi C, et al. Immunohistochemical analysis of rhododendrol-induced leukoderma in improved and aggravated cases. J Dermatol Sci 2020; 99(2): 140-143.<\/span><\/li>\n
      • Iriyama S, Yasuda M<\/strong>, Nishikawa S, et al. Decrease of laminin-511 in the basement membrane due to photoaging reduces epidermal stem\/progenitor cells. Sci Rep 2020; 10(1): 12592.<\/span><\/li>\n<\/ul>\n<\/section>\n
        \n

        \u30b0\u30eb\u30fc\u30d7\u306e\u30e1\u30f3\u30d0\u30fc\u306e\u53d7\u8cde<\/h4>\n

        \u5b89\u7530 \u6b63\u4eba<\/h5>\n

        \u25a02019\u5e74\u5ea6\u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662GCP\u8cde<\/p>\n

        \u6817\u5c71 \u88d5\u5b50<\/h5>\n

        \u25a02014<\/span>\u5e74\u7b2c78<\/span>\u56de\u65e5\u672c\u76ae\u819a\u79d1\u5b66\u4f1a\u6771\u90e8\u652f\u90e8\u5b66\u8853\u5927\u4f1a\u30dd\u30b9\u30bf\u30fc\u8cde<\/p>\n

        \u25a02019<\/span>\u5e74\u7fa4\u99ac\u5927\u5b66\u5927\u5b66\u9662\u793e\u4f1a\u8ca2\u732e\u30d7\u30ed\u30b0\u30e9\u30e0\u512a\u79c0\u8cde<\/p>\n

        \u25a02021<\/span>\u5e74\u7b2c120<\/span>\u56de\u65e5\u672c\u76ae\u819a\u79d1\u5b66\u4f1a\u7dcf\u4f1a\u512a\u79c0\u6f14\u984c\u8cde<\/p>\n

        \u25a02021<\/span>\u5e74\u7b2c68<\/span>\u56de\u5317\u95a2\u6771\u533b\u5b66\u4f1a\u7dcf\u4f1a\u512a\u79c0\u6f14\u984c\u8cde<\/p>\n

        \u25a0<\/span>2023\u5e74\u7b2c122\u56de\u65e5\u672c\u76ae\u819a\u79d1\u5b66\u4f1a\u7dcf\u4f1a\u512a\u79c0\u6f14\u984c\u8cde<\/p>\n

        \u25a0<\/span>2025\u5e74\u7b2c124\u56de\u65e5\u672c\u76ae\u819a\u79d1\u5b66\u4f1a\u7dcf\u4f1a\u512a\u79c0\u6f14\u984c\u8cde<\/p>\n

        \u5c71\u5d0e \u54b2\u4fdd\u91cc<\/h5>\n

        \u25a0<\/span>2022<\/span>\u5e74\u7b2c26<\/span>\u56de\u5317\u95a2\u6771\u533b\u5b66\u4f1a\u5968\u52b1\u8cde<\/p>\n

        \u4e95\u4e0a \u88d5\u592a<\/strong><\/h5>\n

        \u25a0<\/span>2024\u5e74\u5317\u95a2\u6771\u533b\u5b66\u4f1a\u5968\u52b1\u8cde<\/p>\n

        \u9f4b\u85e4 \u664b\u592a\u90ce<\/h5>\n

        \u25a02020\u5e74\u65e5\u672c\u76ae\u819a\u79d1\u5b66\u4f1a\u30fb\u96d1\u8a8c\u8ad6\u6587\u8cde<\/span><\/p>\n<\/section>\n

        \n

        \u30b0\u30eb\u30fc\u30d7\u306e\u7279\u5fb4<\/h4>\n

        \u76ae\u819a\u306f\u4eba\u4f53\u6700\u5927\u306e\u81d3\u5668\u3068\u8a00\u3048\u308b\u7d44\u7e54\u3067\u3059\u304c\u3001\u4e00\u53e3\u306b\u76ae\u819a\u3068\u8a00\u3063\u3066\u3082\u3001\u982d\u76ae\u3001\u5507\u3001\u4f53\u3001\u624b\u306e\u3072\u3089\u30fb\u8db3\u306e\u88cf\u306a\u3069\u90e8\u4f4d\u306b\u3088\u3063\u3066\u3001\u305d\u306e\u6027\u72b6\u3084\u6a5f\u80fd\u306f\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002\u518d\u751f\u533b\u7642\u304c\u76db\u3093\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u6628\u4eca\u3067\u3059\u304c\u3001\u4f53\u4e2d\u306e\u76ae\u819a\u3092\u518d\u751f\u3055\u305b\u308b\u305f\u3081\u306b\u306f\u76ae\u819a\u306e\u305d\u308c\u305e\u308c\u306e\u90e8\u4f4d\u306e\u9055\u3044\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u305d\u308c\u305e\u308c\u306e\u90e8\u4f4d\u3084\u69cb\u9020\u304b\u3089\u69d8\u3005\u306a\u76ae\u819a\u60aa\u6027\u816b\u760d\u304c\u767a\u751f\u3057\u307e\u3059\u3002\u76ae\u819a\u306e\u9055\u3044\u304c\u660e\u3089\u304b\u306b\u306a\u308c\u3070\u3001\u76ae\u819a\u60aa\u6027\u816b\u760d\u306e\u6cbb\u7642\u3078\u306e\u5fdc\u7528\u3082\u671f\u5f85\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u76ae\u819a\u306b\u306f\u307e\u3060\u307e\u3060\u4e0d\u601d\u8b70\u306a\u3053\u3068\u304c\u305f\u304f\u3055\u3093\u3042\u308a\u307e\u3059\u3002\u8208\u5473\u304c\u3042\u308b\u65b9\u306f\u3001\u662f\u975e\u4e00\u7dd2\u306b\u7814\u7a76\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n<\/section>\n

        \n

        \u5171\u540c\u7814\u7a76\u8005<\/h4>\n

        \u5409\u91ce\u3000\u8061\uff08\u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u3000\u5185\u5206\u6ccc\u7cd6\u5c3f\u75c5\u5185\u79d1\uff09
        \n\u9ad8\u6a4b\u5065\u9020\uff08\u7409\u7403\u5927\u5b66\u533b\u5b66\u90e8\u3000\u76ae\u819a\u79d1\u5b66\u6559\u5ba4\uff09
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        \n\u4e2d\u6751\u6cf0\u5927\uff08\u57fc\u7389\u533b\u79d1\u5927\u5b66\u56fd\u969b\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u3000\u76ae\u819a\u816b\u760d\u79d1\u30fb\u76ae\u819a\u79d1\uff09
        \n\u85e4\u6fa4\u5eb7\u5f18\uff08\u611b\u5a9b\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u3000\u76ae\u819a\u79d1\u5b66\u6559\u5ba4\uff09
        \n\u4e2d\u6751\u5143\u6a39\uff08\u540d\u53e4\u5c4b\u5e02\u7acb\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u3000\u52a0\u9f62\u30fb\u74b0\u5883\u76ae\u819a\u79d1\uff09
        \n\u7dd2\u65b9\u3000\u5927\uff08\u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u4e2d\u592e\u75c5\u9662\u3000\u76ae\u819a\u816b\u760d\u79d1\uff09
        \n\u8449\u5c71\u60df\u5927\uff08\u65e5\u672c\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\u677f\u6a4b\u75c5\u9662\u3000\u76ae\u819a\u79d1\uff09<\/p>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

        \u7814\u7a76\u5ba4\u7d39\u4ecb \u7814\u7a76\u30e1\u30f3\u30d0\u30fcLABORATORY MEMBERS \u5b89\u7530\u3000\u6b63\u4eba\uff08\u30b0\u30eb\u30fc\u30d7\u8cac\u4efb\u8005\uff09 \u6817\u5c71\u3000\u88d5\u5b50 \u5c71\u5d0e\u3000\u54b2\u4fdd\u91cc \u4e95\u4e0a\u3000\u88d5\u592a \u9f4b\u85e4\u3000\u664b\u592a\u90ce \u7814\u7a76\u30c6\u30fc\u30de \u8868\u76ae\u89d2\u5316\u6a5f\u69cb\u30fb\u89d2\u5316\u75c7\u7814\u7a76 \u90e8\u4f4d\u7279\u7570\u7684\u8868\u76ae\u89d2\u5316\u6a5f\u69cb\u306e\u89e3\u660e \u76ae\u819a\u306e\u6700 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":11,"menu_order":48,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-41","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/dermatol-h.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/41","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dermatol-h.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dermatol-h.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dermatol-h.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dermatol-h.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=41"}],"version-history":[{"count":8,"href":"https:\/\/dermatol-h.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/41\/revisions"}],"predecessor-version":[{"id":857,"href":"https:\/\/dermatol-h.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/41\/revisions\/857"}],"up":[{"embeddable":true,"href":"https:\/\/dermatol-h.dept.med.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/11"}],"wp:attachment":[{"href":"https:\/\/dermatol-h.dept.med.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=41"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}