{"id":834,"date":"2025-06-11T23:47:50","date_gmt":"2025-06-11T14:47:50","guid":{"rendered":"https:\/\/dermatol-h.dept.med.gunma-u.ac.jp\/?page_id=834"},"modified":"2025-10-06T17:53:50","modified_gmt":"2025-10-06T08:53:50","slug":"834-2","status":"publish","type":"page","link":"https:\/\/dermatol-h.dept.med.gunma-u.ac.jp\/?page_id=834","title":{"rendered":"\u95a2\u53e3\u30b0\u30eb\u30fc\u30d7"},"content":{"rendered":"<section>\n<h4>\u7814\u7a76\u5ba4\u7d39\u4ecb<\/h4>\n<h5>\u7814\u7a76\u30e1\u30f3\u30d0\u30fc<span class=\"marL10 cyan very_small\">LABORATORY MEMBERS<\/span><\/h5>\n<p>\u95a2\u53e3 \u660e\u5b50\uff08\u30b0\u30eb\u30fc\u30d7\u8cac\u4efb\u8005\uff09<br \/>\n\u4e95\u7530 \u6893<br \/>\n\u99ac \u5f0b\u7136<br \/>\n\u4e2d\u6751 \u82f1\u7384\u3000\uff08\u7fa4\u99ac\u5927\u5b66\u5f62\u6210\u5916\u79d1\uff09<br \/>\n\u6a2a\u5c71 \u6d0b\u5b50<br \/>\n\u837b\u91ce \u5e78\u5b50<br \/>\n\u9ce5\u5c45 \u826f\u5b50<br \/>\n\u7dbf\u8cab 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class=\"bold\">\u53c2\u8003\u8ad6\u6587<\/span><\/h6>\n<p>\u25a0Sekiguchi A, et al. Inhibition of skin fibrosis via regulation of Th17\/Treg imbalance in systemic sclerosis. Sci Rep 2025;15:1423.<br \/>\n\u25a0Sekiguchi A, et al. Topical sirolimus suppresses skin fibrosis in a bleomycin-induced mouse model of systemic sclerosis. J Dermatol Sci 2025;118:45-48.<br \/>\n\u25a0Sekiguchi A, et al. Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress. J Dermatol Sci 2019; 96: 8-17.<br \/>\n\u25a0Sekiguchi A, et al. Prevalence and clinical characteristics of earlobe crease in systemic sclerosis: Possible association with vascular dysfunction. J Dermatol. 2020;47:870-875.<br \/>\n\u25a0Motegi SI, Sekiguchi A, et al. Prevalence and clinical characteristics of overactive bladder in systemic sclerosis. Mod Rheumatol. 2020;30:327-331.<br \/>\n\u25a0Motegi SI, Sekiguchi A, et al. Demographic and clinical characteristics of spinal calcinosis in systemic sclerosis: Possible association with peripheral angiopathy. J Dermatol. 2019;46:33-36.<br \/>\n\u25a0Motegi SI, Sekiguchi A, et al. Extragenital lichen sclerosus successfully treated with narrowband-UVB phototherapy. Eur J Dermatol. 2018;28:710-711.<br \/>\n\u25a0Motegi SI, Sekiguchi A, et al. Successful treatment of Raynaud&#8217;s phenomenon and digital ulcers in systemic sclerosis patients with botulinum toxin B injection: Assessment of peripheral vascular disorder by angiography and dermoscopic image of nail fold capillary. J Dermatol. 2018;45:349-352.<\/p>\n<h5>\u96e3\u6cbb\u6027\u76ae\u819a\u6f70\u760d\uff08\u8925\u7621\u3001\u7cd6\u5c3f\u75c5\u6027\u6f70\u760d\uff09\u306e\u75c5\u614b\u89e3\u660e\u3068\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a<\/h5>\n<p>\u79c1\u305f\u3061\u306f\u3001\u8925\u7621\u3084\u7cd6\u5c3f\u75c5\u6027\u6f70\u760d\u306a\u3069\u306b\u4ee3\u8868\u3055\u308c\u308b\u96e3\u6cbb\u6027\u76ae\u819a\u6f70\u760d\u306e\u75c5\u614b\u3068\u6cbb\u7642\u306b\u95a2\u3059\u308b\u57fa\u790e\u30fb\u81e8\u5e8a\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u8d85\u9ad8\u9f62\u793e\u4f1a\u306b\u304a\u3044\u3066\u6df1\u523b\u306a\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u8925\u7621\u306b\u6ce8\u76ee\u3057\u3001\u305d\u306e\u767a\u75c7\u30fb\u96e3\u6cbb\u5316\u306e\u80cc\u666f\u3068\u306e\u95a2\u9023\u3092\u7814\u7a76\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u8925\u7621\u306f\u9ad8\u9f62\u8005\u306e\u751f\u6d3b\u306e\u8cea\u3092\u5927\u304d\u304f\u640d\u306a\u3046\u75be\u60a3\u3067\u3042\u308a\u3001\u3055\u3089\u306b\u533b\u7642\u8cbb\u3084\u4ecb\u8b77\u8ca0\u62c5\u306e\u5897\u52a0\u3068\u3044\u3063\u305f\u793e\u4f1a\u7684\u5f71\u97ff\u3082\u7121\u8996\u3067\u304d\u307e\u305b\u3093\u3002\u79c1\u305f\u3061\u306f\u3001\u3053\u3046\u3057\u305f\u80cc\u666f\u3092\u3075\u307e\u3048\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u4e88\u9632\u30fb\u6cbb\u7642\u6cd5\u306e\u78ba\u7acb\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u3001\u8925\u7621\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u78ba\u7acb\u3057\u3001\u30dc\u30c4\u30ea\u30cc\u30b9\u6bd2\u7d20\u3084\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u306e\u5c40\u6240\u6295\u4e0e\u306b\u3088\u3063\u3066\u6f70\u760d\u5f62\u6210\u3092\u6291\u5236\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u6210\u679c\u306f\u3001\u8925\u7621\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u4e9c\u925b\u6b20\u4e4f\u304c\u8925\u7621\u306e\u767a\u751f\u30fb\u9077\u5ef6\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u7d4c\u53e3\u7684\u306a\u4e9c\u925b\u88dc\u5145\u306b\u3088\u308a\u5275\u50b7\u306e\u6539\u5584\u304c\u671f\u5f85\u3067\u304d\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002\u9ad8\u9f62\u8005\u3067\u306f\u6f5c\u5728\u7684\u306a\u4e9c\u925b\u6b20\u4e4f\u304c\u3057\u3070\u3057\u3070\u898b\u9003\u3055\u308c\u3066\u304a\u308a\u3001\u7a4d\u6975\u7684\u306a\u8840\u6e05\u4e9c\u925b\u5024\u306e\u6e2c\u5b9a\u3068\u88dc\u5145\u304c\u3001\u8925\u7621\u306e\u6cbb\u7642\u3060\u3051\u3067\u306a\u304f\u4e88\u9632\u306b\u3082\u3064\u306a\u304c\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u6210\u679c\u306f\u30012019\u5e74\u5ea6\u65e5\u672c\u8925\u7621\u5b66\u4f1a\u3000\u5927\u6d66\u8cde\u3092\u53d7\u8cde\u3059\u308b\u306a\u3069\u3001\u4e00\u5b9a\u306e\u8a55\u4fa1\u3092\u3044\u305f\u3060\u3044\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3082\u3001\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u304f\u5275\u50b7\u7ba1\u7406\u306e\u5b9f\u73fe\u306b\u5411\u3051\u3066\u3001\u57fa\u790e\u3068\u81e8\u5e8a\u306e\u4e21\u9762\u304b\u3089\u53d6\u308a\u7d44\u307f\u3092\u9032\u3081\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<h6>\u53c2\u8003\u8ad6\u6587<\/h6>\n<p>\u25a0Nakamura H, Sekiguchi A, et al. Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin. J Dermatol Sci. 2019;95:62-69.<br \/>\n\u25a0Sekiguchi A, et al. Botulinum toxin B suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model: Possible regulation of oxidative and endoplasmic reticulum stress. J Dermatol Sci. 2018;90:144-153.<br \/>\n\u25a0Motegi SI, Sekiguchi A, et al. Protective effect of mesenchymal stem cells on the pressure ulcer formation by the regulation of oxidative and endoplasmic reticulum stress. Sci Rep. 2017;7:17186.<span><\/span><\/p>\n<h5>\u5f53\u305f\u308a\u524d\u306b\u6f5c\u3080\u300e\u306a\u305c\uff1f\u300f\u3092\u79d1\u5b66\u3059\u308b\u3002<\/h5>\n<p>\u76ae\u819a\u79d1\u3067\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u6027\u30a4\u30dc\u3084\u52a0\u9f62\u306b\u3088\u308b\u30a4\u30dc\u306b\u5bfe\u3057\u3066\u3001\u6db2\u4f53\u7a92\u7d20\u3092\u7528\u3044\u305f\u51cd\u7d50\u7642\u6cd5\u304c\u3088\u304f\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u6cbb\u7642\u306e\u969b\u3001\u51cd\u7d50\u76f4\u5f8c\u306b\u533b\u5e2b\u304c\u6307\u5148\u3067\u60a3\u90e8\u3092\u6e29\u3081\u3066\u6025\u901f\u306b\u89e3\u51cd\u3059\u308b\u3068\u3044\u3046\u624b\u6280\u304c\u3001\u9577\u5e74\u6163\u7fd2\u7684\u306b\u884c\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u307e\u3067\u3053\u306e\u65b9\u6cd5\u306b\u79d1\u5b66\u7684\u306a\u88cf\u4ed8\u3051\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u3053\u3067\u79c1\u305f\u3061\u306f\u3001\u6db2\u4f53\u7a92\u7d20\u306b\u3088\u308b\u51cd\u7d50\u6cbb\u7642\u306e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u3001\u6025\u901f\u306b\u89e3\u51cd\u89e3\u51cd\u3059\u308b\u3053\u3068\u304c\u6cbb\u7642\u52b9\u679c\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u5b9f\u9a13\u7684\u306b\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u51b7\u51cd\u76f4\u5f8c\u306b\u60a3\u90e8\u3092\u6e29\u3081\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306b\u7d44\u7e54\u3092\u7834\u58ca\u3067\u304d\u308b\u3053\u3068\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u6210\u679c\u306f\u3001\u56fd\u969b\u8a8cJournal of Dermatological Science \u306b\u767a\u8868\u3057\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u3001\u3053\u306e\u3088\u3046\u306b\u65e5\u3005\u306e\u8a3a\u7642\u306b\u6f5c\u3080\u300c\u306a\u305c\uff1f\u300d\u3068\u3044\u3046\u7591\u554f\u306b\u6b63\u9762\u304b\u3089\u5411\u304d\u5408\u3044\u3001\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u533b\u7642\u306e\u78ba\u7acb\u3092\u76ee\u6307\u3057\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u73fe\u5834\u306b\u6839\u3056\u3057\u305f\u767a\u60f3\u3092\u5927\u5207\u306b\u3057\u306a\u304c\u3089\u3001\u60a3\u8005\u3055\u3093\u306e\u6cbb\u7642\u306b\u672c\u5f53\u306b\u5f79\u7acb\u3064\u77e5\u898b\u3092\u751f\u307f\u51fa\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u3001\u79c1\u305f\u3061\u306e\u4f7f\u547d\u3067\u3059\u3002<\/p>\n<h6>\u53c2\u8003\u6587\u732e<\/h6>\n<p>\u25a0Sekiguchi A, et al. Rapid thawing enhances tissue destruction in a mouse model of cutaneous cryoablation: Insights into oxidative stress and neutrophil activation. J Dermatol Sci. 2025;118:9-17.<\/p>\n<h5>\u65b0\u3057\u3044\u8996\u70b9\u3092\u53d6\u308a\u5165\u308c\u305f\u7814\u7a76\u306e\u5c55\u958b\u3078<\/h5>\n<p>\u30b0\u30eb\u30fc\u30d7\u8cac\u4efb\u8005\u306f\u3001\u7c73\u56fdNational Institutes of Health\uff08NIH\uff09\u306b\u7559\u5b66\u3057\u3001\u91cd\u75c7\u85ac\u5264\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u75c5\u614b\u89e3\u660e\u306b\u304a\u3044\u3066\u3001\u30b7\u30f3\u30b0\u30eb\u30bb\u30ebRNA\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u306a\u3069\u306e\u5148\u7aef\u7684\u624b\u6cd5\u3092\u7528\u3044\u305f\u7814\u7a76\u306b\u643a\u308f\u308a\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u57f9\u3063\u305f\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u306e\u77e5\u8b58\u3068\u6280\u8853\u3092\u6d3b\u304b\u3057\u3001\u4eca\u5f8c\u306f\u3053\u308c\u307e\u3067\u306e\u30a6\u30a7\u30c3\u30c8\u306a\u7814\u7a76\u306b\u52a0\u3048\u3066\u3001\u30c7\u30fc\u30bf\u99c6\u52d5\u578b\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3082\u7a4d\u6975\u7684\u306b\u53d6\u308a\u5165\u308c\u3066\u3044\u304f\u65b9\u91dd\u3067\u3059\u3002\u81e8\u5e8a\u3068\u57fa\u790e\u3092\u3064\u306a\u3050\u65b0\u3057\u3044\u8996\u70b9\u3092\u5927\u5207\u306b\u3057\u306a\u304c\u3089\u3001\u3088\u308a\u7cbe\u7dfb\u306a\u75c5\u614b\u7406\u89e3\u3068\u6cbb\u7642\u6226\u7565\u306e\u69cb\u7bc9\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/section>\n<section>\n<h4>\u30b0\u30eb\u30fc\u30d7\u306e\u7279\u5fb4<\/h4>\n<p>\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u65e5\u3005\u306e\u8a3a\u7642\u306e\u4e2d\u3067\u751f\u307e\u308c\u308b\u300c\u306a\u305c\uff1f\u300d\u3068\u3044\u3046\u554f\u3044\u3092\u5927\u5207\u306b\u3057\u306a\u304c\u3089\u3001\u5f37\u76ae\u75c7\u3084\u96e3\u6cbb\u6027\u76ae\u819a\u6f70\u760d\u306a\u3069\u306e\u75be\u60a3\u306b\u5bfe\u3057\u3066\u3001\u57fa\u790e\u3068\u81e8\u5e8a\u306e\u4e21\u9762\u304b\u3089\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u514d\u75ab\u3084\u8840\u7ba1\u3001\u8178\u5185\u7d30\u83cc\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u8996\u70b9\u304b\u3089\u75c5\u614b\u306b\u8feb\u308a\u3001\u5b9f\u969b\u306e\u6cbb\u7642\u306b\u6d3b\u304b\u305b\u308b\u77e5\u898b\u3092\u7a4d\u307f\u91cd\u306d\u3066\u304d\u307e\u3057\u305f\u3002\u7814\u7a76\u306e\u30c6\u30fc\u30de\u306f\u3001\u73fe\u5834\u306b\u6839\u3056\u3057\u305f\u30ea\u30a2\u30eb\u306a\u8ab2\u984c\u3070\u304b\u308a\u3067\u3001\u533b\u7642\u3068\u7814\u7a76\u3092\u3064\u306a\u3050\u3084\u308a\u304c\u3044\u3092\u5b9f\u611f\u3067\u304d\u307e\u3059\u3002\u843d\u3061\u7740\u3044\u305f\u96f0\u56f2\u6c17\u306e\u4e2d\u3067\u3001\u7570\u306a\u308b\u5c02\u9580\u6027\u3092\u6301\u3064\u30e1\u30f3\u30d0\u30fc\u3068\u5354\u529b\u3057\u306a\u304c\u3089\u3001\u81ea\u5206\u306e\u30da\u30fc\u30b9\u3067\u7740\u5b9f\u306b\u529b\u3092\u4f38\u3070\u305b\u308b\u74b0\u5883\u3067\u3059\u3002\u5c11\u3057\u3067\u3082\u8208\u5473\u3092\u6301\u3063\u3066\u3044\u305f\u3060\u3051\u305f\u3089\u3001\u305c\u3072\u6c17\u8efd\u306b\u8997\u3044\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<form name=\"fm\">\n<div class=\"textBox1 cc\"><input type=\"text\" name=\"e1\" readonly=\"readonly\" value=\"asekiguchi\" onfocus=\"this.select(); 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